Free Radical Biology and Medicine is the premier forum for publishing groundbreaking research in the redox biology of both health and disease. We focus on signal transduction and redox signaling; oxidative stress; reductive stress; redox stress; nitrosative stress; aging and age-related diseases; metabolic regulation and metabolic diseases; mitochondrial function and signaling; homeostatic mechanisms and adaptive responses; redox chemistry and mechanisms; materials & nanomaterials; non-thermal plasmas; microorganisms, fungi, plants, insects, animals, and humans; and antioxidant enzymes, pathways, and networks. We welcome both full-length and short Research Communications, Hypothesis Papers, Reviews, Mini Reviews, Graphical Reviews, and Critical Methods Papers. Free Radical Biology and Medicine also commissions themed Special Issues aimed at highlighting recent advances in both basic and clinical fields, with a particular focus on mechanisms underlying altered metabolism and redox signaling.