General The Journal of Steroid Biochemistry and Molecular Biology is devoted to new experimental and theoretical developments in areas related to steroids including vitamin D and lipids. The Journal is interested in functional analyses of signal transduction pathways, impact on molecular phenotypes, metabolic remodeling, and metabolomics of steroids. The Journal publishes a variety of contributions, including original articles, general and focused reviews, and rapid communications (brief articles of particular interest and clear novelty). Selected cutting-edge topics are addressed in Special Issues managed by Guest Editors. Special Issues contain both commissioned reviews and original research papers to provide comprehensive coverage of specific topics, and all submissions undergo rigorous peer-review prior to publication. Scope Manuscripts relating to unsolved issues in genetics, molecular biology, biochemistry, structural biology, steroid chemistry, cell biology, molecular medicine, translational research and clinical medicine, are encouraged. Furthermore, the Journal publishes results on functional association studies and 'omics' that are instrumental in our understanding of complex human diseases. Specific aims Studies on signal transduction pathways, functional annotation of genes and kinetics of metabolic pathways Analyses of mechanisms underlying homeostasis in health and disease Provision of steroid-related tools, synthesis and analysis methods, and reference data Creation of enduring and validated resources for metabolomics and systems biology analyses Enhancement of our understanding, and the development of approaches to study the interplay between the environment, genomes, metabolism and disease Exclusion criteria for manuscripts We do not accept data that have been as a whole or in part published elsewhere (does not apply to data that has been deposited in a data repository or documents that have been posted on a preprint server) We do not accept case descriptions or clinical descriptions of cohorts without analyses of mechanisms leading to changed phenotypes We do not accept observations collected by experiments in a single cell line reagents that are not validated (e.g. antibodies that are not characterized, origin and identity of cells that are not depicted) We do not accept data based on technical replicates rather than biological replicates, or the use of inappropriate statistical analyses We do not accept GWAS without functional analyses explaining associations or at least a functional discussions on correlations US National Institutes of Health (NIH) voluntary posting ("Public Access") policy Journal of Steroid Biochemistry and Molecular Biology and Elsevier facilitate the author's response to the NIH Public Access Policy. For more details please see the Guide for Authors.