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Toxicology in Vitro CA PubMed AJ SCIE JCR:Q3 中科院3区
发文量 6,872
被引量 163,846
影响因子(2023) 1.976

Toxicology in Vitro publishes original research papers, reviews and workshop reports focusing on the application and use of in vitro and in silico systems for toxicological evaluations (collectively described as New Approach Methodologies (NAM)). This includes the utilisation or the development of NAMs for assessing the potential adverse effects of chemicals for human safety assessment. In vitro techniques include primary cells, tissue slices, cell lines and stem cells (adult, embryonic and induced Pluripotent cells) or subcellular preparations thereof. Our journal strongly supports the Reduction, Refinement and Replacement (3R) of animals in toxicology evaluations. This is a wide topic and thus we have certain preferences including: Development of in vitro techniques and their application to research and regulatory use (i.e. 3R principle. Mechanistic underpinning of data. Ability to translate outcome to human safety assessment. We strongly encourage : The use of normal (non-transformed) human cells (where appropriate). Reporting the Short Tandem Repeat (STR) profile of the cells used (especially when cells have been provided as a gift or generated in house). Free access to raw (or primary) data. Appropriate model characterisation. The use (or reduction) of animal free components, including serum. [Especially when the system was already developed under such conditions, such as the HK-2 cell line]. Attention to detailed methodology and appropriate statistics. [Readers need to know how you did the experiment, how many times, how many replicates etc?] Reporting the source of the compounded tested, catalogue no. and lot no. Where the chemical has been purified or synthesised a full analytical report is expected. Quantification of compounds in exposure medium and/or cells over time (biokinetics). We do not accept solely in vivo investigations and rarely accept animal in vivo, in vitro hybrid papers, except where the animal data was critical in the interpretation or validation of the in vitro data (and not merely confirmatory). We generally discourage investigations relating: Unidentified mixtures - for example in plant extracts. Solely pharmacological investigations (e.g. demonstrating your chemical kills cancer cells in vitro is not generally acceptable). Use of non-human cells when human equivalents exist and are available. The lack of adherence to established protocols, without direct explanation. Reporting cytotoxicity alone, with no mechanistic underpinning and/or no estimation of chemical exposure.

  • 主办单位： PERGAMON-ELSEVIER SCIENCE LTD
  • 出版周期： 双月刊
  • 别名： 体外毒理学:与BIBRA联合出版的国际杂志
  • 国际标准连续出版物号： ISSN 0887-2333
  • 创刊时间： 1987年
热门主题：

CellsCytotoxicityEffectsExposureMUin VitroCellAPOPTOSISToxicityOxidative StressSignificantConcentrationsChemicalsAssayInductionPotentialInhibitionCompoundsConcentrationActivation

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目录
封面
2015年01期
共：62篇

      不详

    • Pfaller, WalterPrieto, PilarDekant, WolfgangJennings, PaulBlaauboer, Bas J.

      1-3

    • Mueller, Stefan O.Dekant, WolfgangJennings, PaulTestai, EmanuelaBois, Frederic

      4-6

    • Limonciel, AliceMoenks, KonradStanzel, SvenTruisi, Germaine L.Parmentier, CelineAschauer, LydiaWilmes, AnjaRichert, LysianeHewitt, PhilipMueller, Stefan O.Lukas, ArnoKoppSchneider, AnnetteLeonard, Martin O.Jennings, Paul

      7-18

    • Mueller, Stefan O.Guillouzo, AndreHewitt, Philip G.Richert, Lysiane

      19-26

    • Savary, Camille C.Jiang, XiaoqiAubry, MarcJosse, RozennKoppSchneider, AnnetteHewitt, PhilipGuillouzo, Andre

      27-35

    • Pomponio, GiulianaSavary, Camille C.Parmentier, CelineBois, FredericGuillouzo, AndreRomanelli, LucaRichert, LysianeDi Consiglio, EmmaTestai, Emanuela

      36-51

    • Broeders, Jessica J. W.Parmentier, CelineTruisi, Germaine L.Josse, RozennAlexandre, ElianeSavary, Camille C.Hewitt, Philip G.Mueller, Stefan O.Guillouzo, AndreRichert, Lysianevan Eijkeren, Jan C. H.Hermens, Joop L. M.Blaauboer, Bas J.

      52-61

    • Bellwon, P.Truisi, G. L.Bois, F. Y.Wilmes, A.Schmidt, T.Savary, C. C.Parmentier, C.Hewitt, P. G.Schmal, O.Josse, R.Richert, L.Guillouzo, A.Mueller, S. O.Jennings, P.Testai, E.Dekant, W.

      62-78

    • Germano, DavideUteng, MariannePognan, FrancoisChibout, SalahDineWolf, Armin

      79-94

    • Aschauer, LydiaCarta, GiadaVogelsang, NadineSchlatter, EberhardJennings, Paul

      95-105

    • Aschauer, LydiaLimonciel, AliceWilmes, AnjaStanzel, SvenKoppSchneider, AnnetteHewitt, PhilipLukas, ArnoLeonard, Martin O.Pfaller, WalterJennings, Paul

      106-116

    • Wilmes, AnjaBielow, ChrisRanninger, ChristinaBellwon, PatriciaAschauer, LydiaLimonciel, AliceChassaigne, HubertKristl, TheresaAiche, StephanHuber, Christian G.Guillou, ClaudeHewitt, PhilippLeonard, Martin O.Dekant, WolfgangBois, FredericJennings, Paul

      117-127

    • Crean, DanielBellwon, PatriciaAschauer, LydiaLimonciel, AliceMoenks, KonradHewitt, PhilipSchmidt, TobiasHerrgen, KarinDekant, WolfgangLukas, ArnoBois, FredericWilmes, AnjaJennings, PaulLeonard, Martin O.

      128-137

    • Schultz, LuiseZurich, MarieGabrielleCulot, Maximeda Costa, AnaelleLandry, ChristopheBellwon, PatriciaKristl, TheresaHoermann, KatrinRuzek, SilkeAiche, StephanReinert, KnutBielow, ChrisGosselet, FabienCecchelli, RomeoHuber, Christian G.Schroeder, Olaf H. U.GramowskiVoss, AlexandraWeiss, Dieter G.BalPrice, Anna

      138-165

    • Belwon, P.Culot, M.Wilmes, A.Schmidt, T.Zurich, M. G.Schultz, L.Schmal, O.GramowskiVoss, A.Weiss, D. G.Jennings, P.BalPrice, A.Testai, E.Dekant, W.

      166-175

    • Vichi, S.Von Tobel, J. SandstroemGemma, S.Stanzel, S.KoppSchneider, A.MonnetTschudi, F.Testai, E.Zurich, M. G.

      176-184

    • Broeders, Jessica J. W.Hermens, Joop L. M.Blaauboer, Bas J.Zurich, MarieGabrielle

      185-191

    • Pomponio, GiulianaZurich, MarieGabrielleSchultz, LuiseWeiss, Dieter G.Romanelli, LucaGramowskiVoss, AlexandraDi Consiglio, EmmaTestai, Emanuela

      192-202

    • Hamon, JeremyRenner, MariaJamei, MasoudLukas, ArnoKoppSchneider, AnnetteBois, Frederic Y.

      203-216

    • Kramer, Nynke I.Di Consiglio, EmmaBlaauboer, Bas J.Testai, Emanuela

      217-224
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2015年01期

2015年01期

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