Small GTPases have emerged as key signal transducing proteins involved in every facet of cell and organismal biology. To reflect their prominence in health and disease, the journal Small GTPases aims to be a dedicated forum for the sharing of information at the forefront of the field, covering a broad range of research including cell and in vivo biology, structural studies, biochemistry, and drug discovery. In addition to the GTPase proteins themselves, Small GTPases features research focused on the structure, regulation, and function of their regulators and effectors. To reflect the advances in methodologies used for biological research, Small GTPases is particularly interested in manuscripts that make use of emerging approaches, including systems biology, biophysics, advanced imaging and, bioinformatics. These approaches complement classical experimental techniques to discover the underlying mechanisms that small GTPases employ to regulate fundamental biological processes.